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Thursday, August 27 • 4:00pm - 4:20pm
[0114] Structural Modifications of Quinoidal Molecules towards Bioactive and Fluorescent Heterocycles

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Over the past five years, our group has employed in design, synthesis and optimization of new heterocyclic compounds with different biological applications.1,3 In this context, we revealed the synthesis and the biological evaluations (e.g. bioimaging, cellular uptake and dynamics in living cells) of some new fluorescent oxazoles and their boron complexes which have allowed for selectively visualizing the whole endocytic pathway. The target compounds were characterized by spectroscopic analyses, single crystal X-ray, photophysics and DFT calculations. In addition, a straightforward synthesis of chalcogen-containing β-lapachones with trypanocidal and antitumor activities and a new probe for alkaline metals are also described from lapachol, an affordable naturally occurring naphthoquinone

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avatar for Eufrânio da Silva Júnior

Eufrânio da Silva Júnior

Eufrânio N. da Silva Júnior received his degree in chemistry from the Catholic University of Brasília (UCB). In 2007, he completed his MSc at the Fluminense Federal University (UFF) and in 2009 he concluded his PhD at the University of Brasilia (UnB). In 2010, he became Professor... Read More →

Thursday August 27, 2015 4:00pm - 4:20pm PDT
Girvetz 2115