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Tuesday, August 25 • 3:40pm - 4:00pm
[0022] Enantiospecific coupling of secondary and tertiary boronic esters

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A great amount of research has been dedicated in recent decade towards developing methods that facilitate the construction of 3D scaffolds of molecules. This comes as a direct consequence of a realisation that saturated molecules interact better with biological receptors than flat, unsaturated structures. There is a strong interest from pharmaceutical industry as it hopes to explore undiscovered chemical space using saturated molecules. Scientific community is investing a lot of effort to enable this goal, mainly by utilisation of established methods such as Suzuki-Miyaura cross-coupling. This Nobel Prize winning process has opened doors to a wide range of stereospecific reactions that enable the synthesis of tertiary carbon centres with high enantiomeric enrichment. This talk will focus on a new process developed in Aggarwal group that allows for the synthesis of tertiary and all-carbon quaternary centres in a transition metal free transformation

ST Lecturers
avatar for Marcin Odachowski

Marcin Odachowski

University of Bristol
MChem University of Manchester, UK Currently: PhD student at University of Bristol, UK

Tuesday August 25, 2015 3:40pm - 4:00pm PDT
Girvetz 2112