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Tuesday, August 25 • 2:40pm - 3:20pm
[0028] Synthesis of Poison-Frog Alkaloids

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A variety of lipid-soluble alkaloids have been detected in amphibian skin, which contains over 20 structural classes and over 800 alkaloids. Many of these poison-frog alkaloids are expected to show interesting biological activities such as inhibitory effects on the neuronal nicotinic acetylcholine receptors (nAChRs).

We envisioned an efficient and flexible synthesis of 5,8-disubstituted, 6,7-dehydro-5,8-disubstituted, and 5,6,8-trisubstituted indolizidines, 1,4-disubstituted quinolizidines, decahydroquinoline-type poison-frog alkaloids using a Michael-type conjugate addition reaction of an enaminoester as the key step as shown below.

Invited Lecturers
avatar for Naoki Toyooka

Naoki Toyooka

Professor, University of Toyama
| Kinki University, Faculty of Pharmaceutical Science  University, 1984.03, Graduated, JAPAN | | | Kinki University, Graduate School, Division of Pharmaceutical Sciences. Doctor's Course, 1989.03, Completed, JAPAN | | | University of Toyama Graduate School of Science... Read More →

Tuesday August 25, 2015 2:40pm - 3:20pm
Corwin East