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Tuesday, August 25 • 2:40pm - 3:20pm
[0028] Synthesis of Poison-Frog Alkaloids

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A variety of lipid-soluble alkaloids have been detected in amphibian skin, which contains over 20 structural classes and over 800 alkaloids. Many of these poison-frog alkaloids are expected to show interesting biological activities such as inhibitory effects on the neuronal nicotinic acetylcholine receptors (nAChRs).

We envisioned an efficient and flexible synthesis of 5,8-disubstituted, 6,7-dehydro-5,8-disubstituted, and 5,6,8-trisubstituted indolizidines, 1,4-disubstituted quinolizidines, decahydroquinoline-type poison-frog alkaloids using a Michael-type conjugate addition reaction of an enaminoester as the key step as shown below.

Invited Lecturers
avatar for Naoki Toyooka

Naoki Toyooka

Professor, University of Toyama
Kinki University, Faculty of Pharmaceutical Science  University, 1984.03, Graduated, JAPAN Kinki University, Graduate School, Division of Pharmaceutical Sciences. Doctor's Course, 1989.03, Completed, JAPAN University of Toyama Graduate School of Science and Engineering... Read More →

Tuesday August 25, 2015 2:40pm - 3:20pm PDT
Corwin East