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Thursday, August 27 • 3:40pm - 4:00pm
[0010] Deprotonated α-Aminonitriles as versatile Building Blocks for the construction of N-Heterocycles

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The strong anion stabilizing capacity of the nitrile group permits a-aminonitriles with a primary or secondary amino group to be used as readily available a-aminocarbanion equivalents after deprotonation with a suitable base. These agents are versatile building blocks for the construction of highly substituted amines and N-heterocycles which can be obtained in very short reaction sequences or one-pot procedures. The related rearrangements of nitrile-stabilized ammonium ylides allow ring transformations such as the construction of protoberberine alkaloids in a single step.


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avatar for Till Opatz

Till Opatz

Full Professor, Johannes Gutenberg-University
Till Opatz studied chemistry at the University of Frankfurt/M., Germany. He received his diploma under the guidance of Prof. Johann Mulzer in 1997. From 1997 to 2001, he worked on his Ph.D. thesis on glucose as a pentavalent scaffold for combinatorial chemistry in the group of Prof. Horst Kunz at the University of Mainz. He then joined the group Prof. Rob M. J. Liskamp at the University of Utrecht, The Netherlands, as a postdoc fellow studying... Read More →



Thursday August 27, 2015 3:40pm - 4:00pm
UCEN Lobero