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Thursday, August 27 • 3:40pm - 4:00pm
[0010] Deprotonated α-Aminonitriles as versatile Building Blocks for the construction of N-Heterocycles

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The strong anion stabilizing capacity of the nitrile group permits a-aminonitriles with a primary or secondary amino group to be used as readily available a-aminocarbanion equivalents after deprotonation with a suitable base. These agents are versatile building blocks for the construction of highly substituted amines and N-heterocycles which can be obtained in very short reaction sequences or one-pot procedures. The related rearrangements of nitrile-stabilized ammonium ylides allow ring transformations such as the construction of protoberberine alkaloids in a single step.

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avatar for Till Opatz

Till Opatz

Prof. Till Opatz, Johannes Gutenberg-University
Till Opatz studied chemistry at the University of Frankfurt/M., Germany. He received his diploma under the guidance of Prof. Johann Mulzer in 1997. From 1997 to 2001, he worked on his Ph.D. thesis on glucose as a pentavalent scaffold for combinatorial chemistry in the group of Prof... Read More →

Thursday August 27, 2015 3:40pm - 4:00pm PDT
UCEN Lobero