ISHC2015 has ended

For Campus Prearrival Information <click here>
For a PDF of the 2015 Program Materials <click here>
For ALL Abstracts [1-220] in sequential order <click here>
For ALL Authors of the Lecture and Poster Presentations <click here>

Back To Schedule
Thursday, August 27 • 3:40pm - 4:00pm
[0006] Towards the Total Synthesis of the Tetranortriterpene Gedunin

Sign up or log in to save this to your schedule, view media, leave feedback and see who's attending!

Limited Capacity seats available

Gedunin (1), which was first isolated from the West African timber Entandrophragma angolense in 1960, has been reported to exhibit a diverse range of biological activities, including antimalarial, antifungal, allergic response, peptic ulcer, anti-cancer, eryptosis, antifilarial, and insecticidal activity. In terms of anticancer activity, however, gedunin (1) was explored through the use of a connectivity map, and found to exhibited antiproliferative activity through the heat shock protein Hsp90. Such compelling biological interest in this compound inspired our group to investigate a synthetic route to gedunin so as to open opportunities for better understanding the underlying biochemical pathways. The lecture will describe our efforts in achieving the construction of a key advanced intermediate and subsequent activities towards total synthesis

ST Lecturers
avatar for Craig Willams

Craig Willams

Assoc. Profrofessor, University of Queensland
Professor University of Queensland

Thursday August 27, 2015 3:40pm - 4:00pm PDT
Corwin East