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Monday, August 24 • 4:40pm - 5:20pm
[0081] Synthesis of Hybrid-1,5 Disubstituted Tetrazoles by Ugi-azide Reaction

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Multicomponent reactions (MCR) are powerful tools toward the synthesis of a large variety of interesting scaffolds even heterocycles. MCR are defined as one pot processes in which three or more reagents are sequentially combined to afford products having the majority of the atoms present in the starting reagents. The main applications of MCR are in Diversity Oriented Synthesis (DOS) and Combinatorial Chemistry (CC). The most important MCR are the isocyanide-based multicomponent reactions (I-MCR) such as Ugi reactions e.g. the classic Ugi-4CR, Ugi-3CR, Ugi-Smiles, Ugi-Nenajdenko, Ugi-Interrupted (Groebke-Blackburn-Bienaymé), and Ugi-azide. This latter allows the synthesis of 1,5-disubstituted Tetrazoles of high interest in medicinal chemistry because their ability to adopt conformations of cis-amide bond of peptides. On this occasion, I will show my results lately published just regarding the use of the Ugi-azide reaction towards the synthesis of 1,5-disubstituted Tetrazole-based hybrid compounds and some of their applications, mainly in medicinal chemistry.


Invited Lecturers
avatar for Rocío Gámez-Montaño

Rocío Gámez-Montaño

Prof. Investigador Titular “A”, Universidad de Guanajuato
La Dra. María del Rocío Gámez Montaño realizo la Licenciatura en Q.F.B. en la Universidad Michoacana de San Nicolás de Hidalgo (U.M.S.N.H),  el posgrado en la Universidad Nacional Autónoma de México (UNAM) donde obtuvo el grado de Doctor en Ciencias Químicas (2001) con la especialidad en el área de Química Orgánica. En 2001-2002  realizo una estancia... Read More →


Monday August 24, 2015 4:40pm - 5:20pm
UCEN Flying A