For Campus Prearrival Information <click here> For a PDF of the 2015 Program Materials <click here> For ALL Abstracts [1-220] in sequential order <click here> For ALL Authors of the Lecture and Poster Presentations <click here>
In the presence of Ph3PBr2 or Ph3PHBF4, 2-substituted 1,1-diphenyl-2,4-dihydro-1H-benzo[d][1,3]oxaphosphinin-1-ium can be synthesized from (2-(diphenylphosphino)phenyl)methanol and an aldehyde in 36-89% yields. These phosphonium salts are bench-stable solids and undergo Wittig olefination with another aldehyde under basic condition (K2CO3 or t-BuOK) to form benzylic vinyl ethers, which are readily hydrolyzed to 1,2-disubstitued ethanones under acidic condition. Therefore, the overall reaction provides a facile route to couple two aldehydes to form 1,2-disubstituted ethanones
