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Monday, August 24 • 4:00pm - 4:20pm
[0004] Asymmetric Synthesis of alpha-Quaternary Substituted Aziridine-2-carboxylates and Application to Amino Acid Synthesis

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 A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described.  The methodology has been utilized to provide straightforward access to novel, biologically relevant α-quaternary amino esters and derivatives starting from readily available precursors.


ST Lecturers
avatar for Maurice Marsini

Maurice Marsini

Senior ScientistBoehringer Ingelheim Pharmaceuticals | August 2011 – Present (3 years 10 months)Ridgefield, CT -Developed and executed an efficient, GMP synthesis of an API candidate utilizing Continuous/Flow Chemistry on 50 kg scale. | -Acted as Chemical Development liaison and provided scale-up support to colleagues for various activities during Pharmaceutical Development. | -Provided scale-up support to colleagues in Discovery... Read More →



Monday August 24, 2015 4:00pm - 4:20pm
MCC Theater