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Monday, August 24 • 4:00pm - 4:20pm
[0099] Protecting Group Free Enantiospecific Total Synthesis of Structurally Diverse Natural Products of Four Different Classes

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A simple, highly diastereoselective, Lewis acid catalyzed coupling of cyclic allylic alcohol with carbazole, resorcinol and indole derivatives has been developed. The method was applied for the enantiospecific total syntheses of structurally diverse natural products such as murrayamine-O, machaeriol-D, ∆8-THC, ∆9-THC, epi-perrottetinene and tetracyclic core of fischerindole and hapalindoles, having wide range of biological activities. Synthesis of both natural products and their enantiomers has been achieved with high atom economy, protecting group free manner and in less than 5 steps longest linear sequence in very good overall yield starting from R-(+) and S-(-)-limonene.

ST Lecturers
avatar for Dattatreya H. Dethe

Dattatreya H. Dethe

Professor, Indian Institute of Technology Kanpur, India
Ph.D: IISC Bangalore (1999-2005) Advisor: Post-doc: ICES, Singapore(Aug.2005-July 2008) Advisor: Prof.K. C. Nicolaou

Monday August 24, 2015 4:00pm - 4:20pm PDT
Corwin East