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Monday, August 24 • 4:40pm - 5:20pm
[0094] Studies Toward the Synthesis of Daphnicyclidin A

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Daphniphyllum alkaloids are a family of complex, polycyclic natural products derived from evergreen shrubs in southern China.  The daphnicyclidins represent a subset of these alkaloids as exemplified by daphnicyclidin A (1).  A stereocontrolled synthesis of the tricyclic ABC ring system will describe the formation of the amine 2 via a novel nine-membered Z-enone.  The discussion will present methodology for an efficient preparation of a-linked bis-enones as well as novel features of reactivity directly leading to functionalized heterocyclic systems.  Applications of this methodology for synthesis of the condensed fulvene of 1 will be described.

Invited Lecturers
avatar for David R Williams

David R Williams

Harry G. Day Professor of Chemistry, Indiana University

Monday August 24, 2015 4:40pm - 5:20pm
Corwin West