For Campus Prearrival Information <click here>
For a PDF of the 2015 Program Materials <click here>
For ALL Abstracts [1-220] in sequential order <click here>
For ALL Authors of the Lecture and Poster Presentations <click here>
The development of the inverse electron demand Diels-Alder (IEDDA) reactions of 1,3,5-triazines has led to the total syntheses of a series of pyrimidine-containing natural products and the preparation of highly functionalized pyrimidine heterocycles.1 The dienophiles of these IEDDA reactions have been limited to electron-rich alkenes and alkynes, such as enamines, ynamines and amidines. Recently, we have discovered that ketones could be employed directly as productive dienophiles in the 1,3,5-triazine IEDDA reactions under conditions, such as using catalytic amount of hydrazine and trifluoroacetic acid. For examples, pyrimidine fused heterocycle 1 and functionalized pyridine-4-amine 2 may be prepared in moderate to excellent yields by applications of the new methods. The details of these investigations will be discussed.