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Monday, August 24 • 11:20am - 12:20pm
[0167] Application of C-H Functionalization Reactions to the Synthesis of Novel Heterocycles

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In the first part of the lecture, a two-step synthesis of structurally diverse 3-aminoindazoles from readily available starting materials will be presented. This sequence includes a one-pot chemoselective electrophilic activation of tertiary amides and nucleophilic addition of hydrazides to form aminohydrazones. These precursors then participate in an intramolecular ligand-free Pd-catalyzed C-H amination. The azaheterocycles synthesized via this approach were further diversified by subsequent deprotection/functionalization and transition Ru-catalyzed C-H arylation. 

In the second part of the presentation, the preparation of tailored novel fluorescent derivatives that features an intramolecular C-H functionalization will be presented. The fluorescent properties can easily be fined tuned by modifying the basic molecular scaffold

Plenaries and Awardees
avatar for André B. Charette

André B. Charette

Professor, Université de Montréal
Born in 1961 in Montréal, André B. Charette received his B.Sc. in 1983 from the Université de Montréal. He then moved south of the border to the University of Rochester to continue his graduate studies. Under the supervision of Robert K. Boeckman Jr., he completed the total synthesis of the ionophore calcimycin, which earned him the degrees of M.Sc. (1985) and Ph.D. (1987). Following an NSERC postdoctoral fellowship at... Read More →



Monday August 24, 2015 11:20am - 12:20pm
Corwin Pavilion