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ISHC2015

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For a PDF of the 2015 Program Materials <click here>
For ALL Abstracts [1-220] in sequential order <click here>
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5:00pm

Conference Registration Corwin Pavilion

5:30pm

Reception UCEN Lagoon Plaza

7:00pm

Dinner Ortega Dining Commons

7:30am

Breakfast Ortega Dining Commons

8:40am

Announcements Corwin Pavilion

9:00am

[0200] Enantioselective Synthesis of Heterocycles from Carbon-Carbon Multiple Bonds Corwin PavilionF. Dean Toste

10:00am

Coffee Break UCEN Lagoon Plaza

10:20am

[0215] The Functionalization of C—H Bonds Corwin PavilionM Christina White

11:20am

[0167] Application of C-H Functionalization Reactions to the Synthesis of Novel Heterocycles Corwin PavilionAndré B. Charette

12:30pm

Lunch Ortega Dining Commons

2:00pm

[0083] Enantioselective N-heterocyclic Carbene Catalysis with Ester Substrates UCEN Flying ADavid Lupton [0202] Development of New Higher-Order Carbocyclization Reactions: Emulating Terpene Biosynthesis Corwin WestP. Andrew Evans [0203] Novel Strategies for the Preparation of Functionalizable Heterocyclic Motifs MCC TheaterAndrew Flick [0205] Nitrogen Dense Heterocycles as Antibiotic Adjuvants Corwin EastChristian Melander

2:40pm

[0057] Enantioselective Organocatalytic Cycloadditions via Hydrogen Bond Catalysis UCEN Flying AGeraldine Masson [0076] To Phlegmarines and Beyond - Strategies for Efficiency and Diversity in Natural Product Synthesis Corwin WestBen Bradshaw [0132] Can Ketones Be Productive Dienophiles For IEDDA Reactions? MCC TheaterXu Bai [0199] Total Synthesis of Periploside A, a unique Pregnane Hexasaccharide with Potent Immunosuppressive Effects Corwin EastBiao Yu

3:20pm

Coffee Break UCEN Lagoon Plaza

3:40pm

[0015] Synthetic Studies Towards Spiroindimicins B-D Corwin WestLachlan Blair [0019] Lewis acid-catalyzed cyclization reactions of amides of ethenetricarboxylates UCEN HarborShoko Yamazaki [0030] Amine Enables the Switching between Iminolactonization and Olefination UCEN StateTakashi Nishikata [0045] Development of an Expedient Process for the Multi-Kilogram Synthesis of CHK1 Inhibitor GDC-0425 Girvetz 2116Andy Stumpf [0087] Catch & Release Drug Delivery System – Heterocycles, Bioorthogonal Chemistry and Implantable Biomaterials Optimize the Pharmacokinetics of Systemic Small Molecules MCC TheaterJose M. Mejia Oneto [0095] Visible light mediated deoxygenation and decarboxylation as key step for the synthesis of tetrahydrofurans and pyrrolidines Corwin EastOliver Reiser [0127] Merging Enamine Catalysis with Hard Metal Lewis Acid Catalysis for Asymmetric Organic Transformations UCEN Flying AHong Wang [0140] The simple and versatile synthesis of tetrasubstituted pyrroles and subsequent functionalization UCEN LoberoTristan Reekie [0165] 1-Aza-3,4-diphospholides - Synthesis, Structure and Reactivity Girvetz 2115Riccardo Suter [0174] Tuberculosinyl Adenosines: Novel Terpene Nucleosides from Mycobacterium tuberculosis Girvetz 2119Jeffrey Buter

4:00pm

[0004] Asymmetric Synthesis of alpha-Quaternary Substituted Aziridine-2-carboxylates and Application to Amino Acid Synthesis MCC TheaterMaurice Marsini [0016] Synthesis of Nitrogen Analogues of Bioactive Lignans Girvetz 2116Eunkyung Jung [0052] Palladium-Catalyzed Amidation by Chemoselective C(sp3)-H functionalization: Concise Route to Oxindoles and its application Corwin WestChihiro Tsukano [0091] A Bioinspired Approach to Tricyclic Spiroacetal-fused gamma-Lactones UCEN HarborRongbiao Tong [0092] Stereoselective Synthesis of Oxa- and Aza-cycles using Reactions of Alkynes Girvetz 2115Santosh J. Gharpure [0099] Protecting Group Free Enantiospecific Total Synthesis of Structurally Diverse Natural Products of Four Different Classes Corwin EastDattatreya H. Dethe [0144] Asymmetric synthesis of β-lactams by gas phase pyrolysis UCEN StateAlan Aitken [0147] One-pot Synthesis of cyclic analogues of hexamethylenebis(3-pyridine)amide (HMBPA UCEN LoberoEduardo González-Zamora [0187] Organotextile Catalysis UCEN Flying AJiwoong Lee [0197] Epimerization-free Cu-catalyzed peptide activation and cyclization Girvetz 2119Jan van Maarseveen

4:20pm

4:40pm

[0081] Synthesis of Hybrid-1,5 Disubstituted Tetrazoles by Ugi-azide Reaction UCEN Flying ARocío Gámez-Montaño [0094] Studies Toward the Synthesis of Daphnicyclidin A Corwin WestDavid R Williams [0129] Synthesis of a Highly Functionalized Octahydro-Isoindole-Based NK1 Receptor Antagonist MCC TheaterJeff Kuethe [0213] α,β-Unsaturated Diazoketones as Useful Platforms in the Synthesis of Nitrogen Heterocycles Corwin EastAntonio Carlos Bender Burtoloso

5:30pm

Poster Session A [0001 - 0115] UCEN Lagoon Plaza

6:30pm

Dinner Ortega Dining Commons

7:30am

Breakfast Ortega Dining Commons

8:55am

Announcements Corwin Pavilion

9:00am

[0079] Studies in Natural Product Synthesis Corwin PavilionPhil Baran

10:00am

Coffee Break UCEN Lagoon Plaza

10:20am

[0204] Transcriptional Control of Cancer with Small Molecules: Towards Novel Therapeutics Corwin PavilionMatthew Shair

11:20am

[0198] Fragment Coupling Using Bimolecular Free-Radical Reactions Corwin PavilionLarry Overman

12:30pm

Lunch Ortega Dining Commons

2:00pm

[0013] Synthesis of Natural Products Containing Spiroketals UCEN Flying AMargaret Brimble [0031] Optimization of Pim Kinase Inhibitors: Heterocyclic Chemistry and Macrocycles in a Pyrrole Series of Compounds MCC TheaterVictor Cee [0046] A Divergent Stereocontrolled Synthesis of the Enantiopure Tetracyclic Cores of Asparagamine A and Stemofoline via an Intramolecular 2-Propylidine-1,3-(bis)silane Bicyclization Corwin EastThomas Livinghouse [0209] Brønsted Acid Catalysis - Concepts and Applications in the Synthesis of Heterocycles Corwin WestMagnus Rueping

2:40pm

[0028] Synthesis of Poison-Frog Alkaloids Corwin EastNaoki Toyooka [0104] Elucidation of the Structure and Stereochemistry of the Metabolites of the HCV Protease Inhibitor Faldaprevir MCC TheaterCarl Busacca [0116] Domino Strategies for Syntheses of Natural Products and New Molecular Scaffolds UCEN Flying AKrishna Kaliappan [0215] Molecular Rearrangements of Furan Heterocycles Corwin WestJavier Read de Alaniz

3:20pm

Coffee Break UCEN Lagoon Plaza

3:40pm

[0011] Rapid Composition of Tricyclic Spiranoid Lactones: Access to Natural and Unexplored Frames Corwin EastDmitry Tsvelikhovsky [0022] Enantiospecific coupling of secondary and tertiary boronic esters Girvetz 2112Marcin Odachowski [0038] Synthesis and Fungicidal Activity of Substituted 1-(1-tert-butyl-1H-imidazol-4-yl)-1H-1,2,3-triazoles UCEN StateMikhail Dubovis [0040] Targeting Vector Borne Tropical Infectious Diseases with Heterocyclic Compounds Girvetz 2115Christina Chai [0062] Ortholactone Spiroketal Fragment Couplings: A Convergent Approach to Complex Natural Products. Corwin WestMatthew Cook [0080] Asymmetric Conjugate Addition of Alkylzirconocenes to Cyclopentene-3,5-dione Monoacetals Girvetz 2116Emeline Rideau [0107] Practical Synthesis of N-Substituted Cyanamides as N-C-N Building Blocks for Heterocycle Synthesis UCEN Flying ATun-Cheng Chien [0123] Small Molecules for Treatment of Retinal Degenerative Diseases MCC TheaterChristopher Lindsey [0146] Synthesis of Highly Functionalized 4-Aminoquinolines Girvetz 2119Tim Wezeman [0169] Development of Chiral Auxiliaries and Catalysts from Proline Hydantoin UCEN LoberoCosta Metallinos [0186] Practical Asymmetric Electrophilic Amination of Silyl Enol Ether Derivatives via the Nitrosocarbonyl Ene Reaction UCEN HarborAndrey Samoshin

4:00pm

[0012] Total and Formal Syntheses of Heterocyclic Natural Products and Drugs by Matsuda-Heck-Reaction Corwin WestFelix Wolf [0017] Transition Metal-Catalyzed Cyclization of Enediynes to Benzopyranones, Carbazoles and Benzothiophenes UCEN Flying AMing-Jung Wu [0069] Fragment-Based Approach Toward Lactate Dehydrogenase A (LDHA) Inhibitors MCC TheaterBeth Knapp-Reed [0105] Teaching an old dog new tricks: chemical biology studies of pyrroloquinazolines UCEN LoberoXiangshu Xiao [0112] Enantioselective Synthesis of Fully Functionalized Chiral Hemiaminals UCEN StateHongming Li [0121p] Indole Directed C-H Activation: Direct Synthesis of Functionalized Carbazole from Indoles via Triple C-H Activation Corwin EastAkhilesh Kumar Verma [0124] Production of Antimicrobial Silver and Magnetite nanoparticles Using Natural Products based on Rosin And Murrh Gums Girvetz 2112Hamad Al-Lohedan [0175] Synthesis and application of 2-substituted 1,1-diphenyl-2,4-dihydro-1H-benzo[d][1,3]oxaphosphinin-1-ium Girvetz 2116Wenhua Huang [0177] Discovery and Optimization of Novel Inhibitors of the Mitochondrial Permeability Transition Pore Girvetz 2119Sudeshna Roy [0211] Towards Chemoselective Arylation Reactions of Peptides Using Triarylbismuthanes Girvetz 2115Martin Hébert [0218] An Efficient Synthesis of Tetrahydroimidazo[1,2-a]pyrazines via Tandem Multicomponent Reaction UCEN HarborVolodymyr Kysil

4:30pm

ISHC Members' Meeting Corwin West

5:30pm

Poster Session B [0116 - 0215] UCEN Lagoon Plaza

6:30pm

Dinner Ortega Dining Commons

7:30am

Breakfast Ortega Dining Commons

8:55am

Announcements Corwin Pavilion

9:00am

[0005] Alan R. Katritzky Memorial Symposium "A 50 Year Infatuation/Obsession with 1,3-Dipoles" Corwin PavilionAl Padwa

10:00am

Coffee Break UCEN Lagoon Plaza

10:20am

[0117] Synthesis of azabicyclic natural product analogues aiming at biological activity Corwin PavilionChristian Stevens

11:00am

[0048] What are Heterocyclic Mesomeric Betaines? Corwin PavilionChristopher Ramsden

11:40am

[0208] Development and Application of StackPhos, A New Chiral Biaryl Heterocyclic Ligand for Enantioselective Catalysis Corwin PavilionAaron Aponick

12:20pm

12:30pm

Lunch Ortega Dining Commons

6:30pm

Dinner Ortega Dining Commons

7:30am

Breakfast Ortega Dining Commons

8:55am

Announcements Corwin Pavilion

9:00am

[0210] Recent Progress in the Synthesis of Natural Products Corwin PavilionJohn Wood

10:00am

Coffee Break UCEN Lagoon Plaza

10:20am

[0078] A. R. Katritzky Junior Award "Synthetic Studies on N-Heterocyclic Natural Products" Corwin PavilionHidetoshi Tokuyama

11:20am

[0155] E. C. Taylor Senior Award: Synthesis of Heterocycles By Cyclizations and Functionalizations Corwin PavilionJanine Cossy

12:30pm

ISHC Committee Lunch GSA Lounge (adjacent MCC) Lunch Ortega Dining Commons

2:00pm

[0066] Carbaporphyrins and Beyond: The Quest for Quatyrin Corwin EastTimothy D. Lash [0192] Developing a Library of Heterocycles to Fight Neglected Diseases UCEN Flying AFlavio Emery [0193] Total Synthesis and Stereochemistry of (+)-Dragmacidin D Corwin WestArmen Zakarian [0196] Old Methods to New Targets: Accessing Highly Functionalized Heterocycles for Drug Development MCC TheaterChristopher Borths

2:40pm

[0002] Mangrolide A – A Novel Marine-Derived Antibiotic with Activity Against Gram-Negative Pathogens Corwin WestJef De Brabander [0073] Polysubstituted Pyrimidines: Biological and Chemical properties UCEN Flying AZlatko Janeba [0194] Synthesis and Up-Scaling of Finerenone, a Novel Potent and Selective Oral Non-Steroidal Mineralo-Corticoid Receptor (MR) Antagonist MCC TheaterJohannes Platzek [0206] "Life is Heterocyclic" (Metalation) Corwin EastVictor A. Snieckus

3:20pm

Coffee Break UCEN Lagoon Plaza

3:40pm

[0006] Towards the Total Synthesis of the Tetranortriterpene Gedunin Corwin EastCraig Willams [0010] Deprotonated α-Aminonitriles as versatile Building Blocks for the construction of N-Heterocycles UCEN LoberoTill Opatz [0014] Hantzsch-type Reaction of β-Formyl-β-nitroenamine: Multi-component Synthesis of 4-Substituted-3,5-dinitro-1,4-dihydropyridine UCEN StateHaruyasu Asahara [0055] N-methylmelamines as precursors for new polymers Girvetz 2116Manuela List [0065] Biomimetic Synthesis of Phenylethanoid Alkaloids Girvetz 2119Patrick Brown [0090] Asymmetric Synthesis of Poison Dart Frog Indolizidine Alkaloids Corwin WestYu-Jang Li [0138] A Straightforward Access to the Chiral Cyclopentadienes via Intramolecular Metal Carbene/Carbenoid Cascade Transformations UCEN Flying AXinfang Xu [0149] Catalytic One-Step Synthesis of Unprotected Piperazines, Morpholines and Thiomorpholines using SnAP Reagents UCEN HarborMichael Umberto Luescher [0156] Enantioselective aza-Henry Reaction of Arylnitromethane using Homogeneous Brønsted Acid-Base Catalyst under Intermittent-Flow Conditions with a Recycle Girvetz 2115Sergey Tsukanov [0189] C-H insertions in oxidative gold catalysis: Synthesis of bicyclic dihydropyran-3-ones from in situ generated α-oxo gold carbenes through the relay of vinyl cation intermediates Girvetz 2112Zhitong Zheng

4:00pm

[0003] Total Synthesis and Structural Revision of Muironolide A UCEN HarborKyle Young [0009] Scale Up of Azaindole Compound: A Story of Synthetic Evolution MCC TheaterColin Liang [0032] Exploration of New Synthetic Methodologies for the Synthesis of Heterocyclic Scaffolds UCEN StateR T Pardasani [0033] Heterocycle Synthesis from Quinols Girvetz 2112Jing Wu [0072] Talkative Molecules: Design and Synthesis of Functional Bodipy Compoundss Girvetz 2116Neelam Shivran [0086] The Total Synthesis of Gelsenicine via Platinum-Catalyzed Cycloisomerization Corwin WestEric Ferreira [0109] Cross-dehydrogenative C-H Bond Silylation of Aromatic Heterocycles by an Earth-abundant Metal Catalyst UCEN Flying AAnton Toutov [0114] Structural Modifications of Quinoidal Molecules towards Bioactive and Fluorescent Heterocycles Girvetz 2115Eufrânio da Silva Júnior [0150] Pyrazoloquinazolinones and benzimidazoquinazolinones via a 3 + 3 N-acylation-SNAr strategy Corwin EastRichard A. Bunce [0217] Synthesis and Conformational Studies of Small Molecule Macrocyclic Inhibitors of ALK/ROS1 – Discovery of PF-06463922 Girvetz 2119Paul Richardson

4:20pm

4:40pm

[0044] Functional Heterocyclic π-Systems by Multicomponent and Domino Syntheses Corwin WestThomas J. J. Müller [0093] Synthesis of a Heterocyclic Pharmaceutical Intermediate via an Intramolecular Asymmetric [3+2] Nitrone/Olefin Cycloaddition MCC TheaterStan Kolis [0207] Molecular Gymnastics: bond formation with rearrangements Corwin EastNuno Maulide [0219] Gold catalysis in the synthesis of heterocycles UCEN Flying ALiming Zhang

5:30pm

Goleta Beach BBQ Goleta Beach

7:30am

Breakfast Ortega Dining Commons

8:55am

Announcements Corwin Pavilion

9:00am

[0195] Toward a nature-inspired, dual-catalytic method to dehydrogenate organic compounds Corwin PavilionErik Sorensen

10:00am

[0201] Complex Natural Products as a Driving Force for Discovery in Organic Chemistry Corwin PavilionBrian Stoltz

11:00am

Closing Remarks by Dan Comins & Oliver Reiser Corwin Pavilion

11:30am

Lunch Ortega Dining Commons